Nanomaterials-enabled diagnostics and imaging for safer and more patient-centric health care & treatment management
AQM's silicon quantum dots and magnetic nanomaterials can be modified with biomolecules to bind to specific circulating cancer cells. Coupled with quantum/magnetic properties, they can be detected and analyzed (e.g., via flow cytometry systems).
Biomolecules like DNA aptamers, Streptavidin, and dyes, from 8 kDa to 150 kDa can be conjugated to our nanomaterials. Our tools provides additional means of monitoring and screening patients with cancers, tumors or other diseases.
We enable quantum sensing, bioimaging, cancer cell detection/therapy, rapid nucleic acid detection with high accuracy and specificity.
Silicon quantum dots represent the next wave of advanced materials that find numerous applications in medicine ranging from drug delivery to biological imaging.
Biomedical Imaging
Fluorescence imaging is used widely to visualize biological processes, as well as cells (in-vivo and in-vitro) and has revolutionized the field of biomedical research. Semiconductor quantum dots have become a critical diagnostic tool for discerning cellular function at the molecular level. Their high brightness, long-lasting, size-dependent, tunability, and narrow luminescence set them apart from conventional fluorescent dyes. Quantum dots are being developed for a variety of biologically oriented applications, including fluorescent assays for drug discovery, disease detection, single protein tracking, and intracellular reporting. Despite these advantages, there are several challenges that QD imaging suppliers face, including heavy metal toxicity, elimination of reagents from the body, and auto-fluorescence from biological chromophores.
AQM has addressed each of the aforementioned challenges with the development of its silicon nanoparticles. Silicon holds considerable potential for in-vivo bioimaging applications due to its intrinsic tunable photoluminescence, non-toxicity, biodegradability and its large specific capacity for drug loading. SiQDs are small, elemental and are biocompatible with the human body. SiQDs will eventually dissolve to form silicic acid, a positive therapeutic and biological compound easily processed through the renal system.
As silicon is an indirect bandgap semiconductor, it has a much longer-lived excited-state than direct bandgap semiconductors such as CdS or CdSe. This property translates to nanoscale silicon and thereby displays photoluminescent lifetimes on the order of 100 ns to several microseconds. By taking advantage of this property, we see the potential for the application of our patented SiQDs for fluorescence in-vivo bioimaging. The remarkably long emission lifetime (5-130 μs) of photoluminescent porous silicon nanoparticles allows time-gated imaging of tissues in-vivo, completely eliminating shorter-lived (<10 ns) emission signals from organic chromophores or tissue auto-fluorescence.
High brightness, optical tunability and long-lasting narrow luminescence set SiQDs apart from conventional fluorescent dyes.
Quantum Diagnostics
SiQDs excel as light-emitting materials with sharp spectral resolution, high quantum efficiency (up to 80%), stable wavelengths, emitting light across visible and near-infrared spectra. In addition, the biocompatibility nature of silicon makes SiQDs an enticing alternative to existing semiconducting quantum dots in the marketplace. AQM has the expertise to produce high-purity SiQDs with customizable surface modifications, including different ligands, biomolecules (nucleic acids, proteins, antibodies, etc.), enabling their use in biology applications.
Dyes as probes have low photostability, photo-bleach, and rapidly degrade. Further, there is the risk of interference with the pH value of the intercellular environment greatly hinder organic dyes’ development in long-term and real-time in bioimaging.
Silicon Quantum Dots attached to a tumor
Magnetic Silicon Quantum Dots